The results showed that one of the compounds synthesized by this method was effective against the drug-resistant strains in the mouse model of bacterial infection. Related papers are published in nature. Most of the antibiotics used in clinic come from natural products. The evolution of these molecules must be accompanied by the co evolution of drug resistance mechanism, so as to shorten the clinical life of any kind of antibiotics. < p > < p > Ian Seiple of the University of California, San Francisco, and colleagues reported a method for the synthesis of streptomycin a, which can avoid the resistance caused by vatase. < p > < p > they first used a basic scaffold of naturally produced streptomycin a, and then added interchangeable molecular building units (which can bind to bacterial cell components, but are not easy to bind to VAT), and a total of 62 streptomycin a analogues were produced. < / P > < p > one of the compounds has antibacterial activity against streptomycin resistant Staphylococcus aureus strains, and is effective in mice model of bacterial infection. In an opinion paper published in the same period, Martin Burke of the University of Illinois at Urbana Champaign and his collaborators believe that this work may contribute to the development of streptomycin a, which can avoid VAT mediated drug resistance and maintain strong antibacterial activity. The iPhone 12 keynote has been recorded in Apple park