Like humans, plants can get sick from viruses. The disease caused by plant virus is the second major disease threatening agricultural production. The virus infection of crops will bring devastating consequences, which may lead to the reduction of yield or even the failure of harvest. So, how do plants resist viruses? Is there a way to resist most of the viruses that threaten crops, so as to ensure the stable yield of food? Chinese scientists have handed in beautiful answers. The journal Science published in the early morning of this year reported the latest research results of Zhao Zhong team of China University of science and technology: found the key factor of plant stem cell immune virus WUSCHEL (WUS) protein, and revealed the broad-spectrum antiviral mechanism of plant stem cells. This study has solved a long-standing and concerned problem and is a pioneering research in the field of plant pathology and plant development. According to Professor Zhao Zhong, just like the human body has immune resistance to many viruses, plants can also rely on their own immune capacity to resist viruses. Although researchers at home and abroad have done a lot of research from RNA interference, autophagy, plant hormones and other aspects, the reason why plant stem cells have broad-spectrum antiviral ability is still unclear, which affects the development of plant anti-virus technology. At present, there are more than 1000 kinds of plant viruses, but the existing anti-virus methods of human can only target at a few viruses; moreover, with the continuous evolution of viruses, the resistance will gradually weaken. < p > < p > in the existing anti-virus biotechnology, “shoot tip virus-free” is rare, which can be applied to most plants and remove viruses from the body, but its deep mechanism has not been revealed. Inspired by stem tip virus-free technology, Zhao Zhong’s team found that WUS is a key antiviral protein existing in plant stem cells after eight years of intensive research. Wus is a very conserved protein in stem cells, which is ubiquitous from lower plants to higher plants. This protein is induced by virus infection, and directly inhibits a class of methyltransferase genes, affecting the assembly of ribosomes, the main organelles involved in protein synthesis, thus reducing the rate of protein synthesis. This will directly lead to the virus can not use plant cells to complete its own protein translation and virus replication, assembly process, thus inhibiting the spread of the virus. < / P > < p > researchers found that WUS protein can also become a “sharp weapon” for other cells to resist virus. Researchers express WUS protein in other plant cells, which can protect plants from virus infection. At the same time, the researchers also examined a variety of viruses and confirmed that WUS protein can inhibit the infection of these viruses to plant cells. This indicates that WUS protein mediated stem cell virus immunity has a broad spectrum. < p > < p > WUS in plant cells can prevent virus replication by disrupting cell protein synthesis and maintain cell health. Design: Chen Lei Liang Yan < / P > < p > this work studied the broad-spectrum antiviral immune activity of plant meristem, and found for the first time that there is such a precise molecular link between virus resistance and meristem maintenance genes. Zhao Zhong said that in the next step, they plan to apply the results to breeding, screen high disease resistance proteins based on protein artificial evolution technology, and transfer biotechnology into a variety of crops to obtain new crop varieties with broad spectrum and high disease resistance. He said that WUS is a conserved stem cell regulatory protein, and its homologous protein exists in a variety of plants. “The broad-spectrum antiviral mechanism mediated by WUS protein can provide a new research idea for anti-virus control of many crops, and bring new dawn to solve the problem of global stable grain yield.” (Zhao Yongxin, fan Qiong, LV Qian) < A= target=_ blank>Global Tech