Although the new coronavirus has become the target of “everyone yelling” in 2020, some types of phages are expected to play a positive role. It is reported that in the environment of abuse of antibiotics, many bacteria have developed strong resistance to antibiotics, leading to the death of some infected patients for lack of “ultimate weapons”.
in order to deal with “super bacteria”, scientists have been trying to find more effective treatment. But the team at Flinders University is looking at a tiny virus, a bacteriophage.
in a new study published in the Journal Microbiology of the British Medical Council, the team from Flinders University in Australia has successfully used phages to target Staphylococcus aureus infection, which may lead to foot ulcers in diabetic patients.
for a large number of diabetic patients, if they unfortunately encounter wound infection and fail to get effective treatment, they may eventually lead to amputation or even death.
vancomycin is still commonly used in clinical treatment, but the resistance of bacteria to vancomycin has become stronger and stronger. But during the experiment, the researchers used a “cocktail therapy,” which attacks Staphylococcus aureus through a mixture of three bacteriophages.
the results showed that this solution also had an ideal therapeutic effect on the local body of mice infected with ulcer. Garedew kifellow, co-author of the study, said:
phages effectively reduce bacterial load and significantly improve wound healing in multi drug resistant Staphylococcus aureus infections, which are comparable or even better than current antibiotic prescription therapies.
although more tests are needed to bring the treatment to clinical use, the team has not yet identified other side effects. In addition to local therapy, we can also imagine other forms of phage therapy.
Peter speck, co-author of the study, added: next, we will combine bacteriophages with dressings to produce specific antibacterial dressings against Staphylococcus aureus.
the biggest advantage of this technology is that it can be stored at room temperature (the combined phage can survive for up to a year), and it is suitable for popularization in hospitals and clinics, even in rural and remote areas.