Genetic human genome editing (hhge) is still not up to the relevant standards for safe and effective application in human beings. Countries should conduct extensive discussion and strict supervision before deciding whether to approve such technology for clinical application. < / P > < p > the International Committee on clinical application of human reproductive genome editing is composed of 18 representatives from 10 national research institutions, including the National Academy of medicine, the National Academy of Sciences and the Royal Society of England. Once the genome of a human embryo has been edited, it should not be used for reproduction unless there is clear evidence that precise genomic changes can lead to reliable results without causing unexpected changes, the report said. At present, no genome editing technology, including CRISPR, can meet this standard. Genome editing refers to the insertion, deletion or replacement of DNA (deoxyribonucleic acid) fragments in specific genes. In theory, genome editing can change specific genetic characteristics, thus not only modifying embryo genes, eliminating genetic diseases, but also enhancing physiological characteristics. However, this “baby design” involves ethical and technical issues. The main danger of editing human embryos is that unexpected “Miss target effects” will occur, and these DNA changes cannot be detected before the embryo is implanted into the mother 。 < / P > < p > the report classifies the potential uses of hhge and creates a six level structure based on the risk profile. If a country decides to approve the application of hhge technology, it should also initially limit the use of hhge technology to the prevention of severe monogenic genetic diseases, and such technology should only be considered when there are no other options, the report said. In addition, the report also provides basic guidance and suggestions for national and international regulation of hhge technology. “More research is needed to verify the effectiveness of genome editing techniques in human embryos to ensure that they can be accurately modified and that there is no miss target effect,” said Kay Davis, CO chair of the Commission < / P > < p > in addition, the report calls for the establishment of an international “scientific advisory group” to assess the proposed use of hhge, to provide periodic updates of relevant technologies, and to assess the results if edited embryos were implanted into mothers. It also recommends the establishment of an international mechanism for clinicians or researchers to report on their plans or use of hhge. After 12 years, “world class Super project” Shantou Bay Tunnel ushers in a historic breakthrough today