It’s not until late in life that we realize that it’s possible that the abnormal blood pressure may be a risk factor for dementia. A large study recently published in nature communications by the Oxford University team provides new evidence for this. Studies have found that hypertension and diabetes have adverse effects on thinking speed and memory in brain healthy people, especially with the increase of blood pressure, cognitive performance is getting worse and worse. < / P > < p > this study is mainly aimed at middle-aged people. More than 22000 subjects with relatively healthy brain (no Alzheimer’s disease, nervous system disease, etc.) from UK Biobank were included in the study, and their cognitive and executive functions were evaluated by brain imaging and cognitive tests. < p > < p > data analysis showed that age was the strongest predictor of executive function, followed by antihypertensive drugs, diabetes and Alzheimer’s disease high-risk gene apoE4 carrying status. Therefore, the research team listed these points as cerebrovascular risk factors. < / P > < p > among the above factors, the research team focused on the impact of elevated blood pressure on cognitive function, and noted that this was manifested in many aspects. First of all, in people who did not take antihypertensive drugs, the performance of executive function gradually decreased with the increase of systolic blood pressure. Secondly, compared with those who did not take antihypertensive drugs, the executive function of patients with hypertension who had been taking antihypertensive drugs was significantly worse. In addition, cognitive function was more stable when systolic blood pressure was controlled below 140 mmHg, but decreased significantly when systolic blood pressure exceeded 140 mmHg. < / P > < p > interestingly, when further considering the effect of age, the decline of executive function with the increase of blood pressure mainly occurs in the 44 – 69 age group, and whether it has developed to need medication or not, the impact is even greater in the non medication group. This was not observed in people over the age of 70. Combined with the imaging results, it was found that some changes in brain structure were closely related to the above-mentioned cerebrovascular risk factors, including the volume of the frontal prefrontal network and the integrity of the white matter connection between different brain regions. < / P > < p > the research team concluded that in relatively healthy people, cerebrovascular risk factors also affect brain structure and cognitive function. “Although it’s just a slight decline in speed of thinking and memory, people don’t even notice it in their daily lives. But being able to detect this change means that the brain has changed and may worsen with age < p > < p > more importantly, prevention should be carried out as soon as possible to avoid further decline of cognitive function. “Every little change in blood pressure is crucial.” One of the research members, Professor Masud Husain, a neuroscientist at Oxford University, pointed out that “even if the blood pressure is only slightly increased, monitoring and treatment may change the brain structure, affect the thinking speed of middle-aged people, and may also reduce the risk of dementia in the future.” Global Tech