The treatment of rabies is a worldwide problem, and the mortality rate is close to 100%. The annual death rate of rabies in China ranks the fourth among all infectious diseases. Recently, the rabies research team of Huazhong Agricultural University published a paper online in the international academic journal Genome Biology, saying that they have made new breakthroughs in the research of revealing the new pathogenesis of rabies. On September 12, Zhao Ling, the corresponding author of the paper, told Science and Technology Daily that they had finally found the key “switch” to inhibit rabies virus. Zhao Ling told reporters that the pathogenic mechanism of rabies is still unclear, which brings great difficulties to the treatment. In addition, after being bitten by a dog, vaccination needs 4 to 5 injections, and some patients will give up halfway, leading to immune failure. Zhao Ling went to the University of Georgia to study for a doctor’s degree in 2004 and began to study rabies virus; in 2012, she returned to her alma mater Huazhong Agricultural University to establish her own research team, which has been engaged in research in this field for eight years. Zhao Ling has two greatest wishes: one is to understand the pathogenic mechanism of rabies virus and make a breakthrough in clinical treatment; the other is to develop new vaccines to reduce the number of vaccinated needles. In this latest paper, they not only made a breakthrough in the pathogenesis of rabies virus, but also found a better drug target. < / P > < p > “this study has been carried out for 5 years. Through high-throughput screening and big data analysis, we are the first to find this target. ” Zhao Ling said it is a key epigenetic protein (EZH2) and a switch that controls downstream gene expression. Turn it off, the downstream gene expression increases, so as to inhibit rabies virus. < / P > < p > “EZH2 is a star molecule, and it has been found that EZH2 can control the growth of tumor, and drugs designed with it can inhibit the expression of tumor related genes.” Zhao Ling said it was the first time that a long non coding RNA (lncrna), named edal, could inhibit the virus by degrading EZH2 in neurons. < p > < p > rabies virus mainly damages the central nervous system, but the basic research of this kind of virus is still lagging behind, and the pathogenesis is not very clear. Therefore, the effective prevention and control and clinical treatment of this kind of viral diseases are facing great difficulties. < / P > < p > “the pathogenic mechanism of rabies virus in the central nervous system has always been a relatively large blank.” Zhao Ling said that the new study found that there are some specific genes in the central nervous system against rabies virus. Previous studies have suggested that rabies virus can proliferate and destroy neurons after entering the brain. There is no host gene in neurons to fight against the virus. Zhao Ling said that the study provides a new idea for further study of the mechanism of the interaction between the neurovirus and the host. On the basis of this mechanism, scientists are expected to find new targets to effectively inhibit the virus, so as to develop specific antiviral drugs. < / P > < p > “with rabies as the model, we can analyze more pathogenic mechanisms of neuroviruses.” Zhao Ling introduced that the central nervous system is the place where the immune response of the human body is weak and vulnerable to virus attack. For example, we are familiar with herpes virus, HIV, Zika virus, etc., in fact, can cause damage to the central nervous system. Zhao Ling said that there is a bigger discovery in this study. Previous international studies have shown that the “on-off” point (EZH2) binding to lncrna is nonspecific, while they have found a specific site, subverting the previous traditional view. < / P > < p > “there is a big difference between specific and non-specific. For example, you can target specific binding and reduce non-specific reaction, which is very helpful for future drug research.” Zhao Ling told reporters that this provides a new direction for future drug research. This study found a key switch to inhibit the virus, and found the key site to control the switch. In the future, we can develop drugs that can both resist virus and cancer. Privacy Policy

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