Fan Chunhai, an academician of Shanghai Jiaotong University, and Yan Hao, Professor of Arizona State University, etc., have created a new type of metadna structure, which can self assemble into micron scale structures with different shapes, which can be used in optoelectronics and synthetic biology, according to a paper published in the latest issue of nature chemistry So as to promote the development of information storage and encryption technology. < / P > < p > the unique characteristics of DNA structure make it a versatile component for complex nanostructures and devices, the researchers explained. With the aid of DNA folding technology, long single stranded DNA (ssDNA) can be folded into specific shapes with the help of hundreds of short DNA strands. However, it has been difficult for scientists to assemble larger DNA structures (micron to millimeter), which limits the wide use of DNA folding technology. < / P > < p > to solve this problem, the research team has developed a general “metadna” (M-DNA) strategy and developed a new type of metadna structure. This new metadna structure is about the same width as human hair silk, and its diameter is 1000 times that of natural DNA nanostructure. The researchers have shown that this submicron six strand DNA structure can self assemble like an enlarged version of single stranded DNA. < p > < p > subsequently, researchers used this metadna to construct a series of submicron to micron DNA architectures, including metajunctions, 3D polyhedrons, and various 2D / 3D lattices. They also demonstrated a layered strand replacement reaction on metadna, which transfers the dynamic characteristics of DNA to metadna. In addition, a series of submicron or micron DNA structures from one dimension to three dimensions, including tetrahedron, octahedron, prism and six closely packed lattices, can be constructed by changing the local flexibility and interaction of single DNA. < / P > < p > researchers say that in the future, they can use these metadna to design more complex circuits, molecular machines and nano devices, and use them in applications related to biosensors and molecular computing. Moreover, this study greatly improves the feasibility of creating dynamic micron DNA structures. The authors of this paper point out that the introduction of this metadna strategy will make DNA nanotechnology leap from nano level to micron level and help scientists create a series of complex static and dynamic structures at submicron and micron scale, thus making many new applications possible. For example, scientists can use these metadna structures to create larger and more complex functional components. < / P > < p > DNA is a kind of natural biological macromolecule, and also a universal component for manufacturing nano scale components and machines. With DNA folding, it can be woven like a sweater and assembled like Lego. Once upon a time, an American scientist folded a long DNA strand into a smiling face. DNA and short strands meet and assemble into different shapes. The new metadna structure developed in this paper is equivalent to the raw material for constructing DNA system structure, thus solving the problem of too small objects involved in DNA folding. In the future, these metadna can become the basis of more complex nano devices and nano robots, and provide better support for information storage, precision medicine and other applications. Global Tech