There is a certain risk of failure in steel implant surgery. For example, the artificial hip joint can not fuse with the surrounding bone smoothly, which will lead to the separation and failure of the two. But a new study, published in the journal polymers, suggests that a new coating could help better anchor the implant to the patient’s bone. In the case of titanium based prostheses, this new polymer coating, which combines fibronectin fragments naturally produced by the human body, can stimulate the proliferation of cells in adjacent bone tissue and enter the coating.
fibronectin fragment, also known as RGD domain, is composed of arginine, glycine and aspartic acid, and its molecules can act as anchor points for hook osteocyte proteins (integrins).
it can not only fix the adjacent bone tissue to the prosthesis, but also communicate with the cells themselves to induce them to adhere to the coating and reproduce. In contrast, uncoated implants lack the RGD domain, which leads to bone cells not considering them as compatible materials.
it is understood that the research collaborators include scientists from the University of Malaga in Spain, the Canary Islands Institute of technology, and biotechnology company osteobionix.
through further research and development, it is expected that the new polymer coating can be mixed with anti-inflammatory drugs and antibiotics to reduce the probability of rejection, infection or other complications.